(https://www.vet.upenn.edu/research/academic-departments/biomedical-sciences/our-research/germ-stem-reproductive-biology/sasaki-laboratory) is focused on the development of human germline and urogenital organs. His team’s major research accomplishment includes
1) the discovery of the nascent amnion as the origin of primate germline,
2) first reconstitution of human primordial germ cell and prospermatogonial development using pluripotent stem cells,
3) identification of the origin of human gonadal and adrenal lineage and
4) the reconstitution of human adrenal specification using pluripotent stem cells. These discoveries lay the foundation for understanding molecular basis of human infertility, reproduction an endocrinology.We are looking for motivated postdoctoral fellows who are interested in the following fields
- 1. Human germline and gonadal development and their reconstitution in vitro.
We aim at establishing methods to derive fertile human sperm in dish in next five years. Through this process, we will decipher the lineage trajectories of developing human male germ cells and the accompanying epigenetic regulation, the specification of human gonadal somatic cells and sex determination and molecular interplays between gonadal somatic cells and germ cells. Our studies on human germ cells and gonadogenesis will transform human reproduction and help humanity thrive in the future.
- 2.Human adrenal development and in vitro reconstitution using pluripotent stem cells
We will establish a method to derive fully functional human adrenal cortex in dish and recreate hypothalamus-pituitary-adrenal axis in patents with primary adrenal insufficiency. Candidate qualifications include
Applications are open until all positions are filled.Please send the following to
ksasaki@upenn.edu
CV
- Summary of research interest and accomplishments
