News announcement

【职位介绍】

Our laboratory studies and develops adoptive T cell therapies targeting solid tumors. The postdoctoral scientist will develop genetically engineered T cells starting from the molecular cloning phase of cell therapy development, and then advancing to preclinical in vitro work and clinically relevant mouse models. An additional focus will be to develop strategies to recruit neoantigen-targeted immunity. A strong background in molecular biology and immunology will allow the successful applicant to be creative within the lab, enhancing T cell function and tumor targeting for optimal patient translation and high impact publication. The postdoctoral scientist will work under the mentorship of lead faculty within the Center for Immunotherapy (CFI), which holds multiple large level grants and houses a highly collaborative group of investigators – including immunologists, molecular biologists, and computational biologists – dedicated to developing immune therapies. More information on the CFIcan be found here: https://www.roswellpark.org/cancer-care/treatments/immunotherapy/about-cfi/team.

Publications by CFI members directly relevant to active areas of research:

Cherkassky, L, et al. CAR T cells with cell-intrinsic checkpoint blockade resist tumor-mediated inhibition. Journal of Clinical Investigation, 2016. PMID: 27454297

Want, M et al. Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer. Oncoimmunology, 2019. PMID: 31069153  

Liu, S, et al. Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer. Journal for ImmunoTherapy of Cancer, 2016. PMID: 31221207

【具体要求】

Qualifications:

Requirements are a Ph.D. or M.D. with background in Immunology or Molecular Biology. Applicants with experience in immune assays, FACS, cell culture, mouse experiments, cell transfections, PCR, and cloning and subcloning into vector constructs are preferred. An enthusiasm for research investigation and strong work ethic are necessary.

【申请方式】

Applicant Instructions:

Interested candidates should provide a CV highlighting previous research work, a brief (<1 page) personal statement, and 3 references. Inquiries and applications should be sent to Leonid Cherkassky, MD at Leonid.Cherkassky@RoswellPark.org.