美国耶鲁大学医学院Dr. Yansheng Liu课题组立足于定量生物质谱技术研究手段，聚焦于分析蛋白质的剂量效应、更新动态、与翻译后修饰；主要研究方向包括癌症、遗传疾病的染色体变异和生物进化。现因课题组进一步发展的需要，拟向国内外招聘博士后（1.计算蛋白质组方向, 2.质谱成像方向）及蛋白质组学方向的Postgraduate Associate (Liu Lab 提供薪酬)。Dr. Yansheng Liu博士现为耶鲁大学医学院药理学系副教授，师从Ruedi Aebersold教授，曾以第一作者在Cell、Nature Biotechnology等发表文章；2018年在耶鲁建组至今，以通讯作者在Nature Biotechnology、Nature Communications、Science Advances、Developmental Cell、Nucleic Acids Research等期刊发表研究论文18篇，并在Science和Cell等发表合著论文。目前文章总数75篇，总引用 >8000次，H-index 34 (谷歌学术)。刘教授目前担任Proteomics编委、Proteomics-Clinical applications编委和Review Commons咨询专家编委。先后为Cell、Nature Biotechnology、Nature Methods、Molecular Cell等期刊审稿120余篇，并担任人类蛋白质组大会（HUPO）颁奖委员会与教培委员会成员、美国蛋白质组学会(US HUPO)顾问委员；获美国质谱学会研究奖（ASMS Research Award）、HUPO ECR青年科学家最佳论文奖等，并于2023年荣获US HUPO的Robert Cotter奖，是少数在HUPO、ASMS、和US HUPO连续斩获青年科学家大奖的学者。Please see the Liu Lab website for more information https://www.yslproteomics.org/1.具有MD或PhD学位，并在毕业后从事正式研究工作两年以上。3.对蛋白质组学有浓厚兴趣，并能专心参与实验室工作一年至两年。4.专业与业务研究能力强，较好的英文写作与交流能力。5.需自筹全部经费与健康保险（有最低要求，可来信咨询）。6.为访问学者提供短期、优秀的科研课题或耶鲁校内合作课题、以及以第一作者发表高质量论文的机会（目前Liu Lab的所有访问学者人均有一篇IF>10的一作或共一作研究论文）。7.为符合要求的访问学者提供Yale Visiting Research Faculty的岗位一年或两年。The successful candidate is expected to work on one of the following directions: 1) Develop and apply bioinformatic workflows for proteomic data analysis; or 2) Develop and apply innovative MALDI-imaging mass spectrometry (MS) approaches.Goal: The overarching goal is to work with the members in the Liu Lab and other talented researchers at Yale to achieve the scientific excellence in revealing fundamental biological roles of protein dynamics, turnover, and post-translational modifications underlying diseases and in translational medicine.Qualifications:The successful candidate will have completed or will soon complete their PhD degree and should have extensive experience in either of the two directions: For the direction of bioinformatics, specific skill requirements include data analysis with statistics, data visualization/ interpretation, script languages such as Python and R, programming experience, and scripting in Linux/UNIX. Experience with computational proteomic analysis is preferred; however, basic knowledge of mass spectrometry but strong background in computational biology will also be considered. For the direction of imaging mass spectrometry (or spatial proteomics), experience with the maintenance and trouble-shooting skills on an imaging MS instrument such as Bruker Flex is preferred; however, remarkable experience with other mass spectrometers will also be considered. For both directions, the candidate is expected to have strong English writing and communication skills, strong motivation in scientific research, and a decent publication record.Training: The Postdoctoral Associate will have the opportunity to gain or expand expertise in mass spectrometry, metabolic and lipidomic analysis, optical imaging, biochemistry, and cell signaling. The lab and department science environment will provide strong mentoring and support to pursue independent directions.Postdoc compensation and benefits will be according to Yale policies. More information about salaries and other resources can be found at https://postdocs.yale.edu/postdocs. Postgraduate Associate Position The successful candidate will work to support the research of the Liu lab and collaborative projects.The primary role of the Postgraduate Associate will be generation of proteomic samples for MS analysis and imaging analysis. The Postgraduate Associate with a computational biological background will be also welcome, whose primary role will be the assistance and participation in proteomic data analysis.Training: The major approaches in the Liu Lab and its collaborators include bottom-up MS, bioinformatics, cell culturing, study of protein dynamics, multi-omic analysis, optical imaging, biochemistry, and cellular signaling. The successful candidate will gain significant exposure to and some hands-on experience in these approaches. Highly motivated and dedicated applicants can also expect to gain training in one or more of the specialize approaches.Mentoring:Dr. Liu will be the primary mentor and will meet regularly with the postgraduate associate. The department and Yale Cancer Biology Institute (YCBI) environment will provide strong mentoring. All members of the team will contribute to providing a supportive learning environment. The Postgraduate associate will participate in joint group meetings and attend research in progress talks and seminars.Education:This position offers an opportunity to gain skills and knowledge that will be highly beneficial for individuals whose career plans include studying towards graduate or medical degrees. Strongly motivated candidates who are looking to enhance their laboratory skills and publication record are strongly encouraged to apply and will be strongly supported in their career goals. Ideally an applicant should be able to commit 2 years to this position.Qualifications: A bachelor’s degree in biological sciences is required. Prior laboratory experience is strongly preferred.If interested, please send CV, a cover letter detailing past and future research interests, or research experience and motivation (for the Postgraduate Associate Position), and names of 2-3 references to yansheng.liu@yale.edu.
Yale University is an affirmative action/equal opportunity employer and welcomes applications from women, persons with disabilities, protected veterans and members of minority groups.
